A complex system is irreducible, and because Reality is always richer than any models, any attempt at "total optimisation" will be just overfitting.
The lack of slack and margins can turn small perturbations into large events.
"Total optimisation" of a human is overclocking, therefore, Slow down.
Related:
‣ Local Rationality Principle
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Some predictions about the evolution and qualities of AI from the perspective of scale-free theories of agency and regulative development No system can fully predict its own future behaviour.